RHOU

RHOU

RHOU: Human Ras homolog gene family, member U
PDB Code: 2Q3H
Description
Cells respond in many ways to environmental changes including altering gene expression, physically moving locations, changes to cell-cell interactions, differentiation and even altering their life spans. This is achieved through a signalling network that consists of several signalling pathways. The network receives multiple signals, interprets the signals, amplified and then transmits the signals. One of the best characterised signalling pathways involves the ras GTPase family. The importance of this family of small GTPases to human health was first recognised through the identification of the human H-Ras, N-Ras and K-Ras genes as being oncogenic.
Unusually for GTPases, RHOU possesses an intrinsically fast guanine nucleotide exchange activity and it has no detectable GTPase activity. Even though at the cellular level RHOU does alter the signalling pathways of the cell because of its altered biochemical properties RHOU is likely to be changing cellular function in an atypical manner as compared with the classical GTPases such as h-Ras.

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