PIM2: Human Proviral Integration Site for MuLV
PDB Code: 2IWI
The Pim kinase family includes three constitutively active serine/threonine kinases (Pim-1, -2, and -3) that function as important mediators of cytokine signaling pathways in hematopoietic cells. Pim-2 plays an important role in tumour progression and is overexpressed in human chronic lymphocytic leukemia and non-Hodgkin lymphomas. Pim-2 prosurvival signaling can protect cancer cells from apotosis and confers resistance to rapamycin. Substrates include the pro-apoptotic protein BAD, which is phosphorylated on serine 112, thus preventing BAD-Bcl-x L interaction and reversing Bad-induced cell death. Pim-2 also phosphorylates SOCS-1 which stabilizes the protein enabling negative feedback of the Jak/STAT pathway.
The Pim kinases are distinguished by a unique hinge-region sequence ERPXPX which removes the +3 hydrogen bond donor and provides potential for the design of specific inhibitors. Pim-2 was crystallized with the ruthenium half-sandwich complex (R)- 5 which is a kinetically-inert metal complex based on the inhibitor staurosporine. Such metal complexes extend the small molecule chemical space previously explored by purely organic scaffolds and produces highly potent inhibitors of the Pim kinases.

Welcome to buy

This form is unable to receive your inquiry from aol, hotmail, gmail or others but company email address.After send online enquiry, we will reply you as soon as possible, if not get any response on time please contact us by Tel or Email.
1. Email: sales@biochemical-bc.net
2. Tel: +86 592 5365887
3.WhatsApp: +86 189 6515 7632
4. Send enquiry online

Please feel free to for: the product
Quotation the product,required sepecifications,inquire about MOQ,
New Sales Promotion,New Products,And any other assistance.

You may also be interested in :

For more information of product, please send the email to sales@biochemical-bc.net