Aldehyde Dehydrogenase from bakers yeast
Aldehyde dehydrogenase from baker's yeast is a tetramer consisting of subunits of approximately 57 kDa. The molecular weights of its monomer, dimer,trimer, and tetramer are 57 kDa, 114 kDa, 171 kDa, and 228 kDa, respectively. The monomers are thought to be assembled into tetramers in a heterologous square arrangement.The enzyme exixts as several different isoforms and is localized in both the cytosol and mitochondria.Direct binding studies with the coenzyme in the absence of aldehyde indicate 4 NAD binding sites per tetrameric molecule.
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