CD172a

CD172a

Specification: 96T 48T 0.1ml 0.2ml 1ml
Inventory: available form stock
Product Description:
CD172a, kwon as signal-regulatory protein α (SIRPα), src homology 2 domain-containing phosphatase substrate-1 (SHPS1), PTPNS1, BIT, MFR, and P84, is a 75-110 kD transmembrane glycoprotein involved in receptor tyrosine kinase coupled signaling pathway. It belongs to Ig superfamily primarily expressed on monocytes/macrophages, granulocytes, dendritic cells and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs).
The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion and phagocytosis. CD47 (IAP) is an extracellular ligand for CD172a. SE5A5 antibody is against CD172a and has weak cross-reaction with CD172b. This antibody is able to block the binding of SIRPα (SIRPα1 and SIRPα2) to CD47.
Structure:  75-110 kD glycoprotein , Signal-regulatorey-protein family, Ig superfamily 
Distribution:  Monocytes/macrophages, granulocytes, dendritic cells, neurons 
Function:    Negative regulation of leukocyte adhesion and transmigration, macrophage fusion, phagocytosis 
Ligand Receptor:  CD47 

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