A first generation cephalosporin, cephalexin is a broad-spectrum, bactericidal antibiotic.The drug is well absorbed orally, and widely distributed throughout the body. It crosses both placental and fetal serum, and is not recommended during pregnancy. It does not enter cerebral spinal fluid in appreciable levels. It also does not show significant levels in breast milk, and may be given to lactating females.
It is effective against most Gram-positive organisms such as beta-hemalytic streptococci, Staphylococcus intermedius and aureus, Proteus mirabili, some E. coli, klebsiella, actinobacillis, pasturella, and salmonella. It, however, does not directly attack mycoplasma, but is useful in secondary infections.The drug is excreted by the kidneys via tubular and or glomerulo secretion
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