YWHAQ

YWHAQ

YWHAQ: Human protein 14-3-3 theta isoform
PDB Code: 2BTP
Description
Phosphorylation of a target protein by a specific kinase alters the characteristics of the protein in a number of ways. One alteration is that the attached phosphate group presents a handle to which other molecules can bind thus forming a complex. Generally, this is how the14-3-3 molecules interact with their target proteins.
14-3-3 proteins are highly conserved eukaryotic proteins that bind to phosphorylated Ser (pS) residues via the two consensus sequences of RXXXpSXP and R(S/X)XpSXP. The functional unit is a dimer and their interaction with the phosphorylated target can result in stabilisation of the protein, alteration of enzyme activity, localisation within the cell, prevention of dephosphorylation and either blockage or mediation of protein interactions. Clinically, an elevated level of 14-3-3 proteins in the cerebrospinal fluid is used as a marker from sporadic Creutzfeldt-Jakob disease.
14-3-3 theta appears to be a specific marker of lung cancer  with lower levels of 14-3-3 proteins in the cancer cells increasing the ability of ionizing radiation to kill the cancerous cells. Lateral sclerosis and injury to motorneurons also results in an up-regulation of 14-3-3 theta。 These results hint at a possible general indicator of a neuronal damage being an increase in the level of 14-3-3 proteins. This is supported by observations that 14-3-3 proteins from the cerebrospinal fluid clear after an infection of bacterial meningitis

Welcome to buy

This form is unable to receive your inquiry from aol, hotmail, gmail or others but company email address.After send online enquiry, we will reply you as soon as possible, if not get any response on time please contact us by Tel or Email.
1. Email: sales@biochemical-bc.net
2. Tel: +86 592 5365887
3.WhatsApp: +86 189 6515 7632
4. Send enquiry online



Please feel free to for: the product
Quotation the product,required sepecifications,inquire about MOQ,
New Sales Promotion,New Products,And any other assistance.

You may also be interested in :

For more information of product, please send the email to sales@biochemical-bc.net