YWHAG: Human protein 14-3-3 gamma isoform
PDB Code: 2B05
Protein phosphorylation by kinases is a major process of instigating and transmitting cellular signals. One potential consequence of the addition of the phosphate group to the target protein is that it forms a ?handle? for other protein such as the 14-3-3 protein to grab. We have determined the structure of the gamma isoform of 14-3-3 bound to a phosphorylated peptide taken from the apoptosis sign-regulating kinase 1.
Creutzfeldt-Jakob disease is diagnosed on the basis of clinical findings and the presence of 14-3-3gamma in the patient’s CSF。 Specifically, the presence of 14-3-3gamma in the CSF is a marker for sporadic CJD. When arterials are damaged 14-3-3gamma was shown to be up-regulated. In human lung cancer. the levels of 14-3-3gamma plus 3 other isoforms are greatly increased as compared to the equivalent normal tissues. In one cell line (HEK293) under standard conditions, a total of 170 binding partners were identified that clustered into proteins involved in regulation of the cytoskeleton, membrane signalling and cell fate. These results suggest that 14-3-3gamma plays a significant role in normal cell function as well as the coordinated response of a cell to damage.

Welcome to buy

This form is unable to receive your inquiry from aol, hotmail, gmail or others but company email address.After send online enquiry, we will reply you as soon as possible, if not get any response on time please contact us by Tel or Email.
1. Email: sales@biochemical-bc.net
2. Tel: +86 592 5365887
3.WhatsApp: +86 189 6515 7632
4. Send enquiry online

Please feel free to for: the product
Quotation the product,required sepecifications,inquire about MOQ,
New Sales Promotion,New Products,And any other assistance.

You may also be interested in :

For more information of product, please send the email to sales@biochemical-bc.net