RND1: Human Rho family GTPase 1
PDB Code: 2CLS
Cells respond in many ways to environmental changes including altering gene expression, physically moving locations, changes to cell-cell interactions, differentiation and even altering their life spans. This is achieved through a signalling network that consists of several signalling pathways. The network receives multiple signals, interprets the signals, amplified and then transmits the signals. One of the best characterised signalling pathways involves the ras GTPase family. The importance of this family of small GTPases to human health was first recognised through the identification of the human H-Ras, N-Ras and K-Ras genes as being oncogenic.
The family of Rho GTPases are involved in cell motility and proliferation through the reorganisation of actin and vesicle trafficking. The small GTPase RND1 appears to play a major role in neuronal development as demonstrated for sensory clone collapse as part of a chemorepulsive axon guidance signalling pathway and the control of dendritic development.
Unlike the classical small GTPases, RND1 has a low affinity for GDP and lacks GTPases activity. Here we present the crystal structure of the GTP-bound active state of RND1 which provides an insight into the reason why this GTPase is catalytically inactive.
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