REM1 + GDP

REM1 + GDP

REM1 + GDP: Human RAS-like GTP-binding protein REM1 in complex with GDP
PDB Code: 2NZJ
Description
Cells respond in many ways to environmental changes including altering gene expression, physically moving locations, changes to cell-cell interactions, differentiation and even altering their life spans. This is achieved through a signalling network that consists of several signalling pathways. The network receives multiple signals, interprets the signals, amplified and then transmits the signals. One of the best characterised signalling pathways involves the ras GTPase family. The importance of this family of small GTPases to human health was first recognised through the identification of the human H-Ras, N-Ras and K-Ras genes as being oncogenic.
The RGK subfamily of small GTPases which includes REM1, GEM, RRAD and REM2 are characterised by sequence changes in the functionally important switch I loop and the G3 (DXXG) motif. These changes result in significant decrease in enzymatic turnover effectively making these proteins GTP binding proteins rather than catalytic enzymes. The significance from a functional point of view is that these proteins are likely to be always in the active state.
The family also has N- and C-terminal extensions that contain Ser/Thr residues that after phosphorylation form a complex with 14-3-3 proteins with a subsequent increase in GEM protein half life. Calmodulin, a protein important in calcium regulation, is also able to bind to GEM. This interaction is linked to one of REM’s cellular functions which is the regulation of calcium channel activity through the beta subunit interaction.
REM1 has been localised to endothelial cells where it controls the morphology of these cells by the development of long cytoplasmic extensions and reorganistion of the actin cytoplasm.

Welcome to buy

This form is unable to receive your inquiry from aol, hotmail, gmail or others but company email address.After send online enquiry, we will reply you as soon as possible, if not get any response on time please contact us by Tel or Email.
1. Email: sales@biochemical-bc.net
2. Tel: +86 592 5365887
3.WhatsApp: +86 189 6515 7632
4. Send enquiry online



Please feel free to for: the product
Quotation the product,required sepecifications,inquire about MOQ,
New Sales Promotion,New Products,And any other assistance.

You may also be interested in :

For more information of product, please send the email to sales@biochemical-bc.net