Pim1 + LY333531 (Ruboxi staurin)

Pim1 + LY333531 (Ruboxi staurin)

Pim1 + LY333531 (Ruboxi staurin): Human Pim-1 in complex with LY333531 (Ruboxistaurin)
PDB Code: 2J2I
Recently we identified LY333531 (Ruboxistaurin) as a potent inhibitor for PIM1 and PIM3 but not for PIM2. IC50s determined from enzyme kinetic assays revealed the following potencies: 200nM (PIM1), 800nM (PIM3) and 22 µM (PIM2).
LY333531 has been initially identified as a PKC-beta-specific inhibitor which reduced the development of diabetic vascular complications in animal models and prevented hyperglycemia-induced impairment of endothelial-dependent vasodilation in healthy subjects. Clinical trials showed that oral administration of LY333531 is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients.
The observed cross reactivity of this inhibitor suggests that LY333531 might also find potential applications for the treatment of hematopoetic malignancies.

Welcome to buy

This form is unable to receive your inquiry from aol, hotmail, gmail or others but company email address.After send online enquiry, we will reply you as soon as possible, if not get any response on time please contact us by Tel or Email.
1. Email: sales@biochemical-bc.net
2. Tel: +86 592 5365887
3.WhatsApp: +86 189 6515 7632
4. Send enquiry online

Please feel free to for: the product
Quotation the product,required sepecifications,inquire about MOQ,
New Sales Promotion,New Products,And any other assistance.

You may also be interested in :

For more information of product, please send the email to sales@biochemical-bc.net