PYCS

PYCS

PYCS: Human pyrroline-5-carboxylate synthetase 1 - aldehyde dehydrogenase domain
PDB Code: 2H5G
Description
The synthesis of the amino acids proline, ornithine and arginine is initiated by a two step process consisting of phosphorylation and an NADPH-dependent reduction of the phosphorylated intermediate, by using glutamate or N-acetyl glutamate as initial substrates.
PYCS is involved in the initial steps of proline synthesis, and is a bifunctional enzyme with two distinct enzyme domains. The kinase domain, which is located at the N-terminus of PYCS, catalyzes the phosphorylation of glutamate to γ-glutamyl phosphate. This intermediate is then reduced to the glutamate-γ-semialdehyde product by the C-terminal oxidoreductase domain of PYCS. The resulting semialdehyde product of this reaction spontaneously cyclizes to form pyrroline-5-carboxylate, which is reduced to proline by a subsequent enzymatic step carried out by the distinct enzyme pyrroline carboxylate reductase.
Mutations in PYCS have been thus far identified only in the kinase domain, and lead to hyperammonemia and deficiencies in ornithine, citrullin, arginine and proline levels, and may be associated with neurodegeneration, cataracts and diseases of connective tissues.
The oxidoreductase domain of PYCS is an atypical member of the aldehyde dehydrogenase (ALDH) superfamily, and is classified as ALDH18A1.

Welcome to buy

This form is unable to receive your inquiry from aol, hotmail, gmail or others but company email address.After send online enquiry, we will reply you as soon as possible, if not get any response on time please contact us by Tel or Email.
1. Email: sales@biochemical-bc.net
2. Tel: +86 592 5365887
3.WhatsApp: +86 189 6515 7632
4. Send enquiry online



Please feel free to for: the product
Quotation the product,required sepecifications,inquire about MOQ,
New Sales Promotion,New Products,And any other assistance.

You may also be interested in :

For more information of product, please send the email to sales@biochemical-bc.net