PYCR: Human Pyrroline-5-Carboxylate Reductase
PDB Code: 2IZZ
Pyrroline-5-carboxylate reductase (PYCR) is a ubiquitously expressed housekeeping enzyme that plays an important role in amino acid metabolism. It mediates the second and final step in the synthesis of proline by catalyzing the NADP(H)-dependent reduction of pyrroline 5 carboxylate, an intermediate produced by pyrroline carboxylate synthase (PYCS). A potential role in maintaining the intracellular redox state and control of apoptosis has been discussed for PYCR. Besides these properties, i.e. involvement in endogenous biochemical pathways, PYCR catalyzes the oxidative biotransformation of the anti-neoplastic agent thioproline.
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