PTPRG D1-D2 domain

PTPRG D1-D2 domain

PTPRG D1-D2 domain: Human Protein Tyrosine Phosphatase Receptor G (PTPRG) D1-D2 domain
PDB Code: 2NLK
Description
PTPRG (Protein Receptor Tyrosine Phosphatase gamma) belongs together with PTPRζ to the R5 subfamily which is characterized by an extracellular region containing an N-terminal carbonic anhydrase-like domain, a single transmembrane domain, and a cytoplasmic region with 2 tandem catalytic tyrosine phosphatase domains. Four splice forms have been reported ( PTPRG-A, -B, -C, and ?S). The longest isoform (A) is truncated by 29 residues in isoform B, isoform C has only a single phosphatase domain and isoform S is an extracellular variant of PTPRG. All four isoforms are expressed in brain, kidney, lung, and heart. PTPRG has been discussed as a tumour suppressor gene. The gene was found to be hyper-methylated in primary cutaneous T-cell lymphoma (CTCL) which results in down-regulation of PTPRG expression. Lower expression levels of PTPRG have been reported for a number of cancerous tissues and several mutations have been isolated from tumour cells. Furthermore expression levels are influenced by estradiol-17beta which suppresses PTPRG expression as well as by linoleic acid, IL-1 and TNFalpha which results in upregulation of PTPRG expression. Here we determined the structure of the entire cytoplasmic domain of PTPRG comprising both catalytic domains (D1 and D2).
 

Welcome to buy

This form is unable to receive your inquiry from aol, hotmail, gmail or others but company email address.After send online enquiry, we will reply you as soon as possible, if not get any response on time please contact us by Tel or Email.
1. Email: sales@biochemical-bc.net
2. Tel: +86 592 5365887
3.WhatsApp: +86 189 6515 7632
4. Send enquiry online



Please feel free to for: the product
Quotation the product,required sepecifications,inquire about MOQ,
New Sales Promotion,New Products,And any other assistance.

You may also be interested in :

For more information of product, please send the email to sales@biochemical-bc.net