PTPRB

PTPRB

PTPRB: Human tyrosine receptor phosphatase beta (PTPRβ)
PDB Code: 2AHS
Description
PTPRβ belongs to the subtype R3 family of tyrosine receptor PTP’s which has currently 8 members in human. This tyrosine phosphatase family consists of enzymes that contain a large extracellular domain composed of multiple fibronectin type III repeats, a single transmembrane segment and one intracytoplasmic catalytic domain. The mouse homologue of PTPRβ has been shown to interact with the angiopoietin receptor Tie-2 and with VE-cadherin, which is an essential adhesion molecule in endothelial adherens junctions. This interaction is mediated by the membrane-proximal extracellular domains of each protein, in independent of the enzymatic activity of this phosphatase and reduces the tyrosine phosphorylation of VE-cadherin resulting in cell layer permeability. PTPRβ has been suggested to play a potential role as a regulator of blood vessel morphogenesis and maintenance and is a candidate gene for inherited vascular malformations related to the Tie-2 gene.

Welcome to buy

This form is unable to receive your inquiry from aol, hotmail, gmail or others but company email address.After send online enquiry, we will reply you as soon as possible, if not get any response on time please contact us by Tel or Email.
1. Email: sales@biochemical-bc.net
2. Tel: +86 592 5365887
3.WhatsApp: +86 189 6515 7632
4. Send enquiry online



Please feel free to for: the product
Quotation the product,required sepecifications,inquire about MOQ,
New Sales Promotion,New Products,And any other assistance.

You may also be interested in :

For more information of product, please send the email to sales@biochemical-bc.net