PDZD3: Human natrium-phosphate cotransporter IIa C-terminal-associated protein 2
PDB Code: 2V90
PDZ domains function as protein-protein interaction modules. The best characterised interaction of the PDZ domain is with the C-terminal 4-5 residues of the target protein that binds in an extended fashion between the betaB strand and the alphaB helix of the PDZ domain. In many cases the protein that contains the PDZ domain contains additional PDZ domains or interaction modules. PDZD3 (IKEPP or PDZK2) is one such protein that contains four PDZ domains within its sequence.
Yeast-2-hybrid experiments identified the protein guanylyl cyclase C as the binding partner to the third PDZ domain of PDZD3 . For the organic cation transporter families such as OCT3, OCTN1 and OCTN2 coexpression with PDZD3 in HEK293 cells causes an increase in cell curface expression and has been shown to be important in localisation of the epithelial Ca2+ channels TRPV5 and TRPV6
Here we present the crystal structure of the 3rd PDZ domain of PDZD3 with a C-terminal mode 1 PDZ binding motif (-Gln-Thr-Arg-Leu-COO-) present on the C-terminus of the domain.

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