NPAC: Human cytokine-like nuclear factor n-pac
PDB Code: 2UYY
A recent study identified a nuclear protein (NPAC) composed of three distinguishable domains to be involved in the sorbitol stress induced activation of the MAP kinase p38α. NPAC has an N-terminal PWWP and an AT hook domain which mediate association to the kinase, and an NAD(H) binding/catalytic domain with unknown substrate specificity which shows homologies to hydroxyacid dehydrogenases such as hydroxyisobutyrate dehydrogenase.
The structure of the catalytic domain was solved and shows the typical hydroxyacid dehydrogenase folding pattern.
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