KLHL7: Human kelch-like 7
PDB Code: 3II7
Kelch-like 7 is a member of the BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The protein consists of a BTB domain, a BACK domain (BTB and C-terminal Kelch), and a C-terminal Kelch domain comprising six Kelch repeats.
KLHL7 is ubiquitously expressed with highest expression levels in heart, nervous system and testis.
KLHL7 was originally identified as an autoantigen in several cancers, neurological diseases as well as Sjögren's syndrome. More recently it has been shown that mutations in the BACK domain of KLHL7 can lead to autosomal-dominant retinitis pigmentosa. Although the precise function for KLHL7 is unknown it is thought by analogy with other family members to function as an E3 ubiquitin ligase in which the Kelch domain forms the substrate recognition unit, while the BTB domain complexes with Cullin3; the BACK domain is thought to represent a helical linker.
Here we report the structure of the Kelch domain of KLHL7 at 1.6 Å resolution.

Welcome to buy

This form is unable to receive your inquiry from aol, hotmail, gmail or others but company email address.After send online enquiry, we will reply you as soon as possible, if not get any response on time please contact us by Tel or Email.
1. Email: sales@biochemical-bc.net
2. Tel: +86 592 5365887
3.WhatsApp: +86 189 6515 7632
4. Send enquiry online

Please feel free to for: the product
Quotation the product,required sepecifications,inquire about MOQ,
New Sales Promotion,New Products,And any other assistance.

You may also be interested in :

For more information of product, please send the email to sales@biochemical-bc.net