KLHL11: Human kelch-like 11
PDB Code: 3I3N
Kelch-like 11 is a member of the BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The protein consists of a BTB domain, a BACK domain (BTB and C-terminal Kelch), and a C-terminal Kelch domain comprising six Kelch repeats.
KLHL11 appears widely expressed as cDNAs have been cloned from a variety of sources including testis, brain, intestine, mammary gland, muscle, embryonic tissue and liver.
The precise function for KLHL11 is unknown. By analogy with other family members like KLHL12, it is suggested to function as an E3 ubiquitin ligase in which the Kelch domain forms the substrate recognition unit, while the BTB domain complexes with Cullin3; the BACK domain is though to represent a helical linker. KLHL11 has been identified as one of the proteins secreted by skeletal muscle and may potentially act locally on muscle cells or on surrounding tissues, or alternatively be released into the blood stream producing systemic effects. KLHL11 is also one of the genes regulated by PPARgamma and its expression is downregulated in colorectal cancer cells treated with PPARgamma agonists.
Here we report the structure of the BTB-BACK domain fusion of KLHL11 at 2.6 Å resolution providing the first structure of a BTB-BACK domain.
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