HIBADH + cofactor

HIBADH + cofactor

HIBADH + cofactor: Human hydroxyisobutyrate dehydrogenase in complex with NAD+
PDB Code: 2I9P
Hydroxyisobutyrate dehydrogenase (HIBADH) catalyzes the NAD-dependent oxidation of hydroxyisobutyrate to methylmalonate semialdehyde, an important intermediate in valine catabolism. The product enters the TCA cycle through further conversion to propionyl-CoA. The enzyme is localized to mitochondria and belongs to the long-chain dehydrogenase/hydroxyacid dehydrogenase family of enzymes.

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