GPX7: Human glutathione peroxidase 7
PDB Code: 2P31
Glutathione peroxidase 7 (GPX7, NPGPX) is a recently identified non-selenocysteine containing phospholipid hydroperoxidase. At least seven glutathione peroxidases (GPX1?7) exist in mammalian cells: cytoplasmic GPX1, gastrointestinal GPX2, secreted GPX3, phospholipid hydroperoxidase GPX4, epididymal GPX5, olfactory GPX6, and non-selenocysteine containing phospholipid hydroperoxidase GPX7. The wild-type enzymes typically contain an active site selenocysteine that is encoded by the UGA stop codon. Replacement of this residue by a cysteine, as occurs in GPX7 and GPX5, dramatically decreases the catalytic activity. Although the majority of mammalian glutathione peroxidases are tetrameric, the phospholipid hydroperoxidases GPX7 and GPX4 are monomeric.
The GPX family constitutes an important mechanism in the protection against oxidative stress by scavenging and inactivating hydrogen and lipid peroxides to water or lipid hydroxyls in a glutathione-dependent reductive reaction. To date GPX7 has not been extensively characterized but it is reported to be cytoplasmic and widely expressed. A role for GPX7 in alleviating oxidative stress in breast cancers induced by dietary fatty acids is postulated.
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