GIPC2 (PDZ domain)
GIPC2 (PDZ domain): Human PDZ domain protein GIPC2
PDB Code: 3GGE
GIPC2, also known as SEMCAP2 constitutes together with GIPC1/GIPC/RGS19IP1 and GIPC3 the human GIPC gene family that is characterized by a central PDZ domain and GIPC homology (GH1 and GH2) domains. GIPC2 is highly expressed in ascending colon, kidney and pancreas.
GIPC2 has been suggested to play a key role in embryogenesis through modulation of growth factor signaling and cell adhesion but the precise biological function needs to be elucidated.
GIPC2 may play a role in carcinogenesis as de-regulated expression has been described in several cancer types. However whereas expression is down-regulated in some primary kidney tumors, primary colon tumors, and primary rectal tumor up-regulated expression has been found in several cases of primary gastric cancer. Aberrant methylation of the GIPC2 gene has also been described in acute lymphoblastic leukemia.
We have determined the structure of the PDZ domain of human GIPC2 at 2.6Å resolution.
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