AASDHPPT + ACP: Human holo-ACP synthase in complex with Coenzyme A and the ACP domain of cytosolic fatty acid synthase
PDB Code: 2CG5
Aminoadipate semialdehyde dehydrogenase 4' phosphopantetheinyl transferase (AASDHPPT, holo ACP synthase) catalyzes the transfer of 4' phosphopantetheinyl moieties from Coenzyme A (CoA) to conserved serine residues in certain carrier proteins such as acyl carrier proteins (ACPs). In humans this modification is essential for the functioning of both mitochondrial and cytosolic fatty acid synthase (FAS) complexes. We determined the complex of human AASDHPPT in complex with CoA and a Ser -> Ala mutant of the human ACP domain of the cytosolic FAS complex.

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