What is Telomerase?

Telomerase is responsible for the the telomere extension of an enzyme in cells, the basic nucleoprotein reverse transcriptase and telomeric DNA can be added to the end of eukaryotic chromosomes.Telomeres in cells of different species for maintaining chromosome stability and cell activity an important role in the telomerase can extend the shortened telomeres (reduced telomerase short telomeres cell replication capacity is limited), so as to enhance the in vitro cellproliferative capacity. Telomerase activity in normal human tissues was inhibited tumor reactivate telomerase may be involved in the malignant transformation. Telomerase important role in the long-term to maintain telomere stability and genome integrity, cell activity and the potential to continue proliferation ability. The presence of telomerase, is to fill the defects of DNA cloning mechanism allows repair the telomeres extend telomere loss does not vary due to cell division and cloning of an increase in the number of the cell division.
However, in normal human cells, telomerase activity is subject to strict regulation, only in hematopoietic cells, stem cells and reproductive cells must keep dividing cells cloned telomerase activity can be detected before . Cell differentiation and maturation must be responsible for a variety of organizations in the body needs, carry out their duties, the telomerase activity will gradually disappear. On the cell itself is whether the continued division of cloning go is not important, but will bear a greater mission differentiation and maturation of cells, tissues and organs is to allow the operation of life-sustaining.

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